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Inflammation was assessed by evans blue plasma extravasation technique and by histology

2.5 In vivo therapeutic effects of Ru SA+AC on ACLT-induced rat OA model Given the remarkable enzyme-like properties, mitochondrial protection, and anti-inflammatory effects demonstrated by Ru SA+AC in vitro, its therapeutic potentials for OA were further investigated based on rat models of OA induced by ACLT, followed by intra-articular injection of g-C 3 N 4 and Ru SA+AC nanozymes

Each sensor protein recognizes specific ligands and undergoes conformational changes upon ligand binding to initiate inflammasome assembly

doi: 10.1126/science.1523409

The increased ROS production during ferroptosis can also contribute to tumor cell proliferation