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Zimmerman HJ, Ishak KG: Valproate-induced hepatic injury: analyses of 23 fatal cases

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Consistent with prior studies 4,24 , ACLY KO cells maintain lower levels of histone acetylation at H3K23 and H3K14 than their WT and ACSS2 KO counterparts, and DKO cells exhibit similar levels of acetylation as single ACLY KO cells (Figure 4A, B)

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Nevertheless, genetic analysis revealed two novel heterozygous mutations in trans of the SLC25A15 gene that in silico analysis further indicated to likely impair the functionality of the transporter protein thus confirming a diagnosis of HHH syndrome