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Furthermore, the transcription factor NFE2 like bZIP transcription factor 2 (NFE2L2, best known as NRF2) is a pivotal regulator of the antioxidant system and controls the expression of genes central to antioxidant defense mechanisms [28]

Inflammation Res (2010) 59(12):9971003

Excess ROS leads to oxidative stress and subsequently damages a wide range of biological molecules including DNA, lipids and carbohydrates, ultimately resulting in cellular damage 3