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10.1002/(SICI)1097-4547(20000215)59:4 3.0.CO;2-9 Summary Keywords zebrafish, hair cell protection, hearing loss, aminoglycosides, hepatocyte growth factor, lateral line Citation Uribe PM, Kawas LH, Harding JW and Coffin AB (2015) Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure

Common (Generally Mild) Nausea Vomiting Headache Mild sedation GI discomfort related to PN Metabolic Effects Elevated homocysteine (risk factor for thrombosis) Metabolic acidosis Hyperammonemia (especially in hepatic dysfunction) Elevated BUN/creatinine Hyperglycemia (from PN carbohydrates) Rare / Serious Hepatic dysfunction Allergic reactions to PN components Central line complications (infection, thrombosis) Refeeding syndrome (hypophosphatemia, hypokalemia, hypomagnesemia) Neurologic symptoms if severe ammonia elevation occurs Pregnancy & Breastfeeding Pregnancy Methionine is naturally required in pregnancy, and PN is considered safe and appropriate when medically indicated