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10.1038/ajg.2009.318 216 YokoyamaH.MasakiT.InoueI.NakamuraM.MezakiY.SaekiC.et al (2019)

PLoS ONE 9:e95319 Sinha AK, Zinta G, AbdElgawad H, Asard H, Blust R, De Boeck G (2015) High environmental ammonia elicits differential oxidative stress and antioxidant responses in five different organs of a model estuarine teleost ( Dicentrarchus labrax )

They can persistently alter the hosts antiviral defenses and disrupt cellular pathways that regulate liver homeostasis, ultimately leading to viral hepatitis and HCC development ( 2.1.1 The impact of selenium on HBV infection HBV infection is the cause of nearly 50% of HCC cases ( 2 SeO 3 ) can suppress HBV protein expression, transcription, and genome replication in a dose- and time-dependent manner in human hepatoma cell lines Huh7 and HepG2.2.15 ( M Na 2 SeO 3 can suppress HBV replication by ~50% in HepG2.2.15 cells by promoting apoptotic cell death and inhibiting cellular inhibitors of apoptosis proteins (cIAPs) ( Figure 1 )

Coenzyme: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that is involved in many cellular processes, including metabolism, DNA repair, and cell signaling

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