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Things Worth Discussing with Your Doctor: Baseline kidney function testing (eGFR and cystatin C) before starting B12 MTHFR genetic testing if you have a family history of kidney disease Comprehensive nutrient testing (magnesium, zinc, B6, folate) Homocysteine and methylmalonic acid baseline levels Regular urinalysis every 3-6 months if youre on high doses Advanced urine tests if youre high-risk Pulse dosing schedules based on your kidney function Optimal timing for taking supplements Creating Your Personal Approach Rather than following generic guidelines, its worth developing an individualized B12 strategy based on your kidney function, genetic factors, and how your body responds to supplementation

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The R144C change in the CYP2C9 * 2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

Therapeutics targeting oxidative stress hold great promise for the treatment of DR but have not yet been translated into clinical practice