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Unlike corticosteroids or broad immunosuppressants, KPV does not appear to suppress immune function globally its NF-kB inhibition is targeted and does not eliminate the immune response, only attenuates the pro-inflammatory cascade

Building upon the initial observation, it is crucial to interpret and apply these findings with caution due to potential variations and discrepancies

In addition, there appears to be activation of the integrated stress response in TCAi cells to counteract redox and amino acid stress

J Biol Chem 274(5):30093016

Furthermore, LS31 promotes the degradation of autophagosomes, facilitating the clearance of intracellular Salmonella and restoring autophagic flux, which limits pathogen proliferation [164]