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Damaged bile duct explants undergo repair with NAC treatment In order to determine whether NAC treatment can mediate repair of EHBD damage in the Mdr2 / mouse, EHBD explants from 2 - and 16-week-old Mdr2 / mice were cultured in a rotating high-oxygenation incubator with cholangiocyte media with or without the addition of NAC for 24 h (Fig

Conclusion This review synthesizes current evidence to summarize the therapeutic potential and underlying mechanisms of nanozymes in IMIDs, while highlighting key challenges and future directions to guide the development and clinical translation of nanozyme-based therapies

Yi Z, Jiang L, Zhao L, et al

Moreover, both HFD and caloric restriction stimulate peroxisome proliferator-activated receptors (PPAR)- and associated pathways, which produce acetyl-CoAs essential for ketogenesis and supply substrates for energy metabolism, hence supporting intestinal development

Arch Biochem Biophys 709:108966