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To further enhance the BBB properties of the models, the medium was supplemented with cARLA (250 M 8-(4-chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, 17.5 M Ro-20-1724, 3 mM LiCl, 3 M A83-01

Chelation therapy is a medical procedure that uses chelating agentssubstances that bind to heavy metals like lead, mercury, aluminum, cadmium, nickel, gadolinium, and arsenicto remove them from the bloodstream