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However, the consistency of these associations remains limited, and clinical guidelinessuch as those issued by the Clinical Pharmacogenetics Implementation Consortium (CPIC)do not currently recommend the use of HTR2A as a standalone clinical biomarker ( Regarding pharmacokinetics, the CYP2D6 and CYP2C19 genes, both part of the cytochrome P450 enzyme family, play a central role in the hepatic metabolism of SSRIs

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