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Another lesson from studies of the effects of DBS is that stimulation of the same sensorimotor targets in the STN- and GPi-DBS are effective in treating a variety of hypo- and hyperkinetic movement disorders

While these findings implicate that RPE pathology may not be of significance in the development of FRDA optic neuropathy, the ability to generate mature ophthalmic cell types from FRDA iPSCs provides hope for a better understanding of the pathological causes of visual defects in FRDA