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This occurs through the reversal of the TCA cycle by -KG derived from glutamine under the action of isocitrate dehydrogenase, which leads to the reduction and carboxylation of NADPH to produce citrate

Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neuro-development and neuroprogression

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For a long time, the prevailing view was that oral glutathione is poorly absorbed that the digestive tract breaks the tripeptide down before it can reach the bloodstream intact

[PubMed: 3126809] 767