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LogP Finally, the most important parameter with respect to mechanism of action of niclosamide on cellular membranes is its LogD, which gives the extent niclosamide partitions into octanol versus water as a function of pH

Most side effects are mild to moderate and improve over time or with dose adjustments

For cardiovascular applications, preclinical protocols suggest early initiation following myocardial infarction provides optimal cardioprotection, with dosing continued for several weeks to months to support sustained repair processes