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New antifibrotic treatments indicated for idiopathic pulmonary fibrosis offer hopes and raises questions

While curtailing lactate mitigates lipid peroxidation, sparing membranes from 4-HNE assault, it risks starving cells of ATP in regions where mitochondria are irreparably damaged [210]

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STAT3 and STAT5 have been reported to act by inhibiting the antitumor immune response by activating, at least in part, the production of inflammatory cytokines (IL-1, IL-17, IL-10, TGF-, or VEGF) and promoting tumor growth and metastasis (150)