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The candidate genes that play a key role in nicotine addiction include those associated with the dopaminergic neurotransmitter system (e.g., DRD2, DRD3, DRD4), cellular transport system (e.g., SLC1A2, SLC6A4), serotonergic neurotransmitter system (e.g., HTR2A), nicotinic neurotransmitter system (e.g., CHRNA4, CHRNA5, CHRNA3, CHRNA7, CHRNB4), opioidergic activity (e.g., OPRM1), and nicotine metabolism (e.g., CYP2A6) ( Figure 1 nAChRs are primary targets of nicotine, nicotine exerts direct and indirect effects on other receptor systems (e.g., opioid, serotonergic, glutamatergic) that also mediate nicotine-induced behavioral and neural changes in humans

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Any little crack in a window could be spotted because thered be a brownish-green stain around ita nicotine stain