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To view a copy of this licence, visit About this article Cite this article Devaux, A., Boucher, D., Villger, R

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Moreover, due to augmentation of GPX4 binding sites provided by the formed nanostructure, Gi-F exhibits increased inhibition of GPX4 activity by assembly enhanced binding ( AEB ) effect in cells, increasing the reactive oxidative species (ROS) produced by FeTCPP-based Fenton reaction

This hierarchical engagement of interconnected cell death modules under palmatine treatment will therefore be the focus of our subsequent research, which will employ TUNEL assay and cell-type-specific co-localization analysis to spatially resolve apoptotic cells and precisely attribute the observed effects to specific hepatic cell populations