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It also suppresses LRP-1 expression while activating NRF2 (NFE2L2) signalling, thereby preserving the integrity of the blood-brain barrier against oxidative stress [74]

In severe cases of vitamin B12 deficiency, like pernicious anemia, regular injections may be required to maintain adequate levels

Conclusion BBB-targeted polypeptide nanoparticles coupled to therapeutic molecules were effectively taken up by brain organoids or showing a BBB protective effect indicating potential applications in nervous system pathologies

Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2/HO-1 pathway