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Anaphylaxis, a potentially life-threatening condition characterized by difficulty breathing and low blood pressure, is a rare but serious reaction that usually begins within 30 minutes of the injection, though it can occur later

Between 85% and 91% of tirzepatide participants reached at least 5% loss versus 35% on placebo, and 57% on the 15 mg dose reached at least 20% loss versus 3% on placebo (PMID 35658024)

People whove had kidney stones in the past may have a greater risk

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Therefore, the commenter requested a reassignment of CPT 92540 from APC 5721 to APC 5722