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Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity

Tian et al., 2011

Nat Prod Res 21:12171220 Ogunyemi OM, Gyebi AG, Adebayo JO, Oguntola JA, Olaiya CO (2020) Marsectohexol and other pregnane phytochemicals derived from Gongronema latifolium as -amylase and -glucosidase inhibitors: in vitro and molecular docking studies

However, the use of analgesics should in no way alter the pathophysiology of the disease and the host immune response, so as not to interfere with the initial scientific study

They found that the disease manifests when patients inherit two copies of the abnormal gene, one from each parent