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(A) Molecular structure of glutathione, (B) the extended, and (C) the folded conformations

In one mechanism, APAP becomes hepatotoxic after its metabolism by CYP2E1 and other P450 isoforms, and produces a reactive metabolite named N -acetyl- p -benzoquinone imine (NAPQI) [110, 271, 272]

Figure 11 Gold nanoparticles (GNPs) have been shown to enhance radiation cytotoxicity in human cancer cells

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Zinc supplementation offers a promising way to mitigate these effects, as it has been shown to reduce symptoms of inflammaging and lower IL-1 release