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Importantly, IDH-1/2 mutations pose an important anti-cancer strategy for hard-to-treat cancer types, these mutations occurring in ~ 7080% of lower-grade gliomas and the majority of secondary glioblastomas and in up to 20% of patients with AML [261, 262]

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& Forsthuber, T

We aimed to describe the association of this SNP and variants of a splice donor-affecting variable-number tandem repeat (VNTR, NG_008938.1:g.22763_22793[16_22]) 243 bp downstream of rs6586282 with severe human sepsis

TfR1 also binds to surface proteins on several viruses (Testi et al., 2019), to a protein needed for infection by the malaria parasite Plasmodium vivax (Testi et al., 2019), and, more recently, to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Liao et al., 2024)