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However, the complex pathogenesis of RA is incompletely understood

In addition to those discussed above, several other antioxidant agents have been tested in experimental animal models for their ability to prevent the vascular and neuronal abnormalities associated with DR (63)

Through these mechanisms, SIRT1 emerges as critical factor in the pathophysiology of CVDs, including heart failure, atherosclerosis, hypertension, and myocardial infarction