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According to research in mice given 5-amino-1MQ showed a 7% reduction in body mass without any changes in food intake, compared to controls

Due to the limited data, it should be avoided by anyone who is pregnant, breastfeeding, or undergoing active cancer treatment

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

Base-calling of automated sequencer traces using phred

Y., Stothard, P