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IR, present in up to 70% of women with PCOS irrespective of obesity, is both a cause and consequence of oxidative imbalance

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Most carriers of the mutation suffer microinfarcts and brain hemorrhages in their twenties, leading to paralysis, dementia, and death in young adults, with an average life expectancy of 30 years 2,3,4,5,6

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NADPH: nicotinamide adenine dinucleotide phosphate