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found a 2-fold increased risk for LUTS in male patients with MetS (81)

2.3 PBPK model validation 2.3.1 PBPK model validation: PK simulations for S-CIT To validate the developed PBPK model of S-CIT, eleven clinical datasets (seven single-dose studies and four multiple-dose studies) were used

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FIGURE 1 Mitochondrial ISC biogenesis has two functions: (1) to synthesize functional clusters in the mitochondria, and (2) to provide an essential precursor to the CIA pathway via the inner membrane exporter ABCB7 (Lill et al., 2015)

Additionally, NRF2 also regulates the expression of the solute carrier family 7 member 11 (SLC7A11), which encodes the cystine/glutamate transporter XCT [23]