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Loss of sex and age-driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice

In the 1980s, Roediger demonstrated that butyrate serves as the primary energy source for colonocytes and that its deficiency compromises epithelial integrity and repair findings that helped establish early mechanistic concepts of the disease [28, 41]

10.1016/j.jpba.2006.04.002 57 NakazibaR.AnyolithoM

These findings indicate that a reduction in NGF does not necessarily compromise trophic support

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