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In agreement, ASMase knockout mice exhibited enhanced hepatotoxicity and liver damage after APAP overdose, while hepatocytes challenged with U18666A, which induces the accumulation of cholesterol in lysosomes, sensitized hepatocytes to APAP-mediated cell death

While injections are the most common method, BPC-157 may also be available in oral or topical forms, though injections are often preferred for their direct and potent effects

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doi: 10.1016/j.neuro.2007.12.002