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See What is the most important information I should know about fondaparinux sodium injection? Severe bleeding.Certain conditions can increase your risk for severe bleeding, including: some bleeding problems some gastrointestinal problems including ulcers some types of strokes uncontrolled high blood pressure diabetic eye disease soon after brain, spine, or eye surgery In children, certain conditions that can increase risk of bleeding, include: systemic lupus erythematous (also known as Lupus) Wilms tumor antiphospholipid syndrome genetic conditions that affect blood clotting cancer decreased red blood cells, white blood cells and platelets (pancytopenia) indwelling chest tubes chest surgery infection severe high blood pressure that affects the brain enlarged or blocked lymph vessels in the small intestine (intestinal lymphangiectasia) Certain kidney problems can also increase your risk of bleeding with fondaparinux sodium injection.Your doctor may check your kidney function during your treatment with fondaparinux sodium injection

Daly AC, Davidson MD, Burdick JA

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Still, the mechanism involved remains unexplained and surprising given that they also increase heart rate and acutely increase cardiac output