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Scott said others who may need B12 supplementation are those on diabetes or acid blocker medication, which can hamper absorption of B12

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Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance

Dave Asprey, founder of Bulletproof and a prominent biohacker, has discussed 5-Amino-1MQ in combination with other peptides, highlighting "a lot of buzz about this peptide especially in combination with the 5-amino 1MQ."[28] He suggests it for biohackers seeking metabolic hacks without extreme diets