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Bjarnason I, Hayllar J, MacPherson AJ, Russell AS

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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

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The only things that could be considered added materials are the components that are used to cool the chilled concrete and heat the heated concrete