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2014;12:2092-103 e2091-2096

The LOX nomenclature is defined by the specific site of their oxygenation product: in humans there are six LOX isoforms 15-LOX-1, 15-LOX-2, 12-LOX-1, 12-LOX-2, E3-LOX, and 5-LOX, of which 12/15-LOX (15-LOX) are the most abundant