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doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

For example, grape seed extract, applied to normal human melanocyte and dermal fibroblast cells, was shown to enhance skin youthfulness by stimulating collagen and elastin production (133)

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Barendrecht MM et al (2007): Is the use of parasympathomimetics for treating an underactive urinary bladder evidence-based

Contrary to these reports, an increase in SAMe levels, together with DNMT1 up-regulation in the tamoxifen-resistant breast cancer cell line TAMR-MCF-7, was reported to lead to PTEN (Phosphatase and tensin homolog) promoter methylation downregulating PTEN expression and increasing Akt phosphorylation