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10.1155/2020/1023297 13 LiuJ.CaiM

Clinical Research Insights

This suggests that AP-1 up-regulation upon loss of Nrf2 might be a compensatory mechanism

Notably, 13 C-glucose tracing revealed delayed labeling of the intracellular pool of fully labeled glucose and tricarboxylic acid cycle metabolites, together with enhanced labeling of pentose phosphate pathway intermediates and glutathione in iNs, indicating a shift toward biosynthetic and antioxidant glucose utilization during differentiation