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Conversely, low expression of gelsolin, apolipoprotein A-IV and the Ig -1 chain C region has also shown diagnostic significance

Lo WK, Yu SM, Chan JC

In general, metabolite levels are likely to differ between cultured cells in vitro and patient tumours in vivo , not least because the composition of common culture media and levels of oxygenation do not recapitulate the physiological environment where tumours form in the body (103)