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Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus) Proc Natl Acad Sci USA

The G site also facilitates the ionization of the sulphydryl group of GSH to yield the highly reactive thiolate anion through hydrogen bonding with an adjacent hydroxyl group

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This cysteine then serves as a substrate for two key enzymes, glutamatecysteine ligase (GCLC) and glutathione synthetase (GSS), which work in sequence to produce the essential antioxidant glutathione (GSH)