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Excess ROS accumulates through multiple PD-related mechanisms, including mitochondrial complex 1 impairment, spontaneous dopamine oxidation and chronic exposure to neurotoxic environmental agents

The 27-plex array analyzed Eotaxin, EGF, Fractalkine, IFN-,IL-1, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-17A, IL-18, IP-10, GRO/KC, TNF-alpha, G-CSF, GM-CSF, MCP-1, Leptin, LIX, MIP-1alpha, MIP-2, RANTES, VEGF

Agonist antibodies were also created targeting DR4 and DR5 due to their favorable half-life and notable preclinical efficacy (Hymowitz et al., 1999

This highly conserved metabolic cycle comprised of two enzymes, GLO1 and GLO2, uses GSH to catabolize MGO to lactate through the intermediate, LGSH (57)

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