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Bioresource Technol 238:129138

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This works by inhibiting tyrosinase, an enzyme involved in the production of melanin (the pigment for both skin and hair)

It combines dorzolamide HCl and timolol maleate

Notably, pharmacological inhibition of either AMPK or autophagy partially restores cell viability but fails to rescue ATP levels, suggesting that hyperactivated mitophagy consumes residual functional mitochondria, thus perpetuating a deleterious feedback loop 32