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In normal healthy tissues, FAS is expressed at very low levels

Standardization process for detection technologies: international unified standards for metabolite quantitative detection must be formulated, encompassing preparation of standard reference materials, analytical methods for detection instrumentation, and operational protocols for quality control, to enhance comparability among results from different studies (166)

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Dark patches are caused by several reasons: Sun exposure increased UV light causes an increase in melanin, and resulting hyperpigmentation Hormonal influences commonly causes melasma and skin hyperpigmentation in women Chemicals chemical irritants can cause pigmentation and discoloration on the skin Acne breakouts after an acne flare, the skin may become discolored, called post-inflammatory hyperpigmentation (PIH), which appears almost as acne scars