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2363-C REDUCTION OF TGF- AND IMPROVEMENT OF FIBROSIS AFTER OPTIMIZATION OF FECAL MICROBIOTA TRANSPLANT WITH AN ENDOSCOPIC-PLACEMENT HYDROGEL IN A MURINE MODEL OF STEATOHEPATITIS WITH FIBROSIS Ramon Bartoli Sole 1,2 , Ignacio Iborra 3 , Maria Torner Sim 3 , Alba Ardevol Ribalta 3 , Helena Masnou 2,3 and Rosa Maria Morillas 1,2,3 , (1)Ciberehd, (2)Germans Trias I Pujol Research Institute (IGTP), (3)Hospital Germans Trias I Pujol Background: Gut microbiota dysbiosis has become a key factor in the development and progression of non-alcoholic steatohepatitis (NASH) by influencing the immune and metabolic systems and increasing gut mucosa permeability to bacterial products, which in turns, activates the secretion of proinflammatory and profibrotic cytokines

These numbers strongly suggest that estrogen replacement and GLP-1/GIP agonism work synergistically in menopausal women

doi: 10.1016/j.jdiacomp.2008.02.002 149 AkbariMOstadmohammadiVLankaraniKBTabriziRKolahdoozFKhatibiSRet al

Increasing fatty acid and ketone metabolism after a ketogenic diet also attenuated reductions in ATP, NAD, mitochondrial fragmentation, and myelination in a murine diffuse axonal injury model, while treatment with ketone bodies reduced neuronal/myelin damage induced by glucose deprivation in vitro [96]