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5.1 Epigenetic regulation and immune remodeling With increasing understanding of maternalfetal immune imbalance, epigenetic regulation and interventions targeting the Treg/Th17 axis have emerged as promising strategies in RPL research

In human brain microvascular endothelial cells and mouse brain microvessels, the pro-inflammatory cytokine Tnf - dramatically increases Icam1 mRNA and protein levels by regulating H3K9me2, which is achieved by treatments with histone methyltransferase G9a and demethylase Kdm4b

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The of 13 increased several-fold (from 0.0170 to 0.323), but and fluorescent lifetime decreased from 0.285 to 0.186 and 3.43 to 2.55 ns, respectively