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Some users report transient mild headaches in the first few days as the brain adapts

The rash is diffuse and still popping up in new locations (not on face, hands, or feet, which is typical of this kind of rash) and has become more itchy over time

Common causes include herniated or bulging lumbar discs (the most frequent cause), spinal stenosis, degenerative disc disease, piriformis syndrome, and spondylolisthesis

Renal TNF- expression is increased in a cisplatin-induced nephrotoxic mouse, and cisplatin-induced renal insufficiency and injury can be significantly alleviated by TNF- inhibition or knockout, indicating that increased TNF- expression plays an important role in cisplatin-induced nephrotoxicity [51]