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Besides inflammation, DNA damage is one of the hallmarks of aging, and highly conserved mechanisms for detecting and repairing DNA damage are important (White et al., 2015

Amino acids, 51(2), 193204

The potential importance of cytosolic pathways in determining glutathione status in cat2 has been previously noted (Mhamdi et al., Genetic studies While the data discussed above provide useful information on biochemical properties and expression patterns, establishing the physiological importance of specific components will require other approaches such as reverse genetics

These residues are conserved between GPx-1 and the highly similar GPx-2, but are not found in GPx-3 or GPx-4

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