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June June 28 Product: Rocket Pharmaceuticals Kresladi Indication: Severe leukocyte adhesion deficiency-I (LAD-I) Rocket Pharmaceuticals announced Friday that the FDA rejected its rare disease gene therapy Kresladi (marnetegragene autotemcel) in a Complete Response Letter requesting limited additional chemistry, manufacturing and controls information to complete the regulators review

Giustina A, Licini M, Bussi AR, Girelli A, Pizzocolo G, Schettino M, et al

Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: SAR, structural insights, and biological characterization

The impairment of the negative feedback was hypothesized to be due to the diminished sensitivity of the glucocorticoid receptors (the glucocorticoid resistance theory) secondary to reduced receptor function and expression, shown in large number of experimental, biological and molecular studies (258)

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