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doi: 10.1016/j.biochi.2009.12.001

In humans, kavain undergoes extensive hepatic metabolism, primarily via cytochrome P450 (CYP) enzyme-mediated pathways, followed by further phase II biotransformation processes such as sulfonation, glucuronidation, and glutathione (GSH) conjugation

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Immunoaffinity 1D4 resin was prepared by conjugating purified, anti-Rho antibody (1D4) to CNBr-activated Sepharose 4B beads (Cytiva)