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Mah E, Pei R, Guo Y, Ballard KD, Barker T, Rogers VE, et al

Infiltrating cells in the CNS interact with pathologically deposited -synuclein molecules, which activate pattern-recognition receptors (TLR2, TLR4) on monocytes and microglia, increasing NF-B activation and inflammasome signaling (NLRP3) [127]