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This compound is more stable than O 2 - , and it can penetrate cell membranes ( ), singlet oxygen (O 2 1 ), and ozone (O 3 ) with strong bactericidal properties ( 2 - + H 2 O 2 OH - + OH - + O 2 ) and the Fenton reaction (H 2 O 2 + Fe 2+ Fe 3+ + OH - + OH - ) with the participation of pro-oxidant ions of transition metals (mostly Fe 2+ /Cu 2+ ) ( In bronchial asthma, ROS act as mediators of asthmatic inflammation and deliver direct pro-asthmatic effects (61)

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For liver and gut microbial metabolites analysis, a hydrophilic interaction chromatography (HILIC) column (Waters Corporation, Milford, MA, USA) with 2.1 150 mm, amide 2.5 m (column that is packed with 2.5 m Ethylene Bridged Hybrid [BEH] particles and Trifunctional Amide as ligand type) was used to separate metabolites

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