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Three consecutive prolines at positions 35 (Pro-Pro-Pro) and an additional proline at position 8 create local conformational rigidity through the unique angle constraints of pyrrolidine-containing residues

The clinical relevance depends on the degree of elevation, persistence of abnormal results, and presence of other symptoms or laboratory abnormalities

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Dose escalation helps restart weight loss in roughly 20-30% of plateau patients, but side effects often worsen and results are unpredictable