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Description

Collectively, these data demonstrated that 2012.2 are ser/gly synthesis-dependent GBM cells, highlighted by increased serine- and glycine-derived synthesis of nucleotides and GSH, as well as adaptive upregulation of PSPH under hypoxic conditions, which could be efficiently targeted by sertraline treatment

Non-clinical studies of progesterone

Depending on the metabolic tasks, the number of mitochondria varies between 10 and 6 x 10 of a cell, and their oxygen requirements vary accordingly

Funding This study was supported by the Canadian Institutes of Health Research (grant number MOP-64345) and in part by the Ontario Ministry of Health and Long Term Care