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de Sa Junior PL, Camara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK

Many clinical trials are constrained by small sample sizes and limited patient diversity, with aged and female patients frequently under-represented, thereby limiting generalizability

Lactate and tumor Tumor adaptation The glycolysis-based metabolic preferences of tumor cells (Warburg Effect) render lactate closely connected with tumor cell metabolism

doi: 10.1590/S1519-99402012000200020 31 LippmanS

Skin Pigmentation and Glutathione Melanogenesis begins with the conversion of L-tyrosine to DOPA-quinone under the effect of tyrosinase enzyme (Figure 1)