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These CO effects require activation of p38 MAPK pathway, which appears to occur via a cGMP-dependent mechanism and require activation of guanylate cyclase as well (Otterbein et al., 2003)

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Guo, L.N

Conjugation reactions by the UGT2B7 enzyme constitute an important step in the metabolism of opioids (Coffman et al., 1998)

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